Hyaluronidase Didn't Dissolve Your RE2O Lump? Why Only Half of It Can Melt
Got a RE2O skin booster, developed a lump, went back for a hyaluronidase injection — but only a little went down, the lump is still there, or it shrinks briefly and comes back? This is not that your dose was too low, and not treatment failure — the main body of RE2O was never dissolvable to begin with. RE2O ships as a powder of human-derived dermal matrix (ADM); at the clinic it is reconstituted — the manufacturer's standard is saline, and only some injectors add a little non-cross-linked hyaluronic acid. Hyaluronidase (the dissolving enzyme) recognizes only hyaluronic acid, so at most it breaks down that added hyaluronic acid, while the ADM particles that actually prop things up will not dissolve. This piece spells out how hyaluronidase works, why it does nothing for ADM, whether collagenase can substitute (and why to stay conservative), and what to do when it won't dissolve.
